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Weight loss, diabetes drugs can cause mood changes: What to know about behavioral side effects [Video]

GLP-1 receptor agonists (GLP-1 RAs), medications that help control type 2 diabetes and obesity, can have a profound impact on physical wellness – but what about mental health?

Some examples of these medications include semaglutides, such as Ozempic and Wegovy, and liraglutide, like Victoza and Saxenda.

Various studies have pointed toward GLP-1 RAs causing mental health complications, such as anxiety and depression.

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The National Institutes of Health (NIH) published research in June 2024 that considered the correlation between semaglutide therapy and “exacerbating mood disturbances.”

The study highlighted the association of negative mood changes in patients with type 2 diabetes with a history of depression, warning healthcare providers to be aware of this “potential risk.”

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Studies have debated the correlation between GLP-1 RA drugs and mood changes.

But a more recent study,published in the journal Diabetes, Obesity and Metabolism, suggested that these mood changes were linked to genetic variations across diverse populations and ancestries …

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